Production of Aniline Derivatives from <i>Cladosporium cladosporioides</i> TFU‐13 and <i>Volutella</i> sp. TFU‐28 in the Presence of SAHA
Biotransformation of suberoylanilide hydroxamic acid (SAHA) by soil-derived Cladosporium cladosporioides TFU-13 and Volutella sp. TFU-28 yielded a panel of aniline derivatives, including two new metabolites (1 and 4) and six previously reported compounds. Structural elucidation of the novel metabolites was conducted using comprehensive nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. Among these, 2-acetamidophenol (6) displayed antioxidant activity, as indicated by diphenylpicrylhydrazyl (DPPH) radical scavenging assays.
Authors
- Minghui Xie (ORCID: https://orcid.org/0000-0002-6443-9608)
- Anwei Hou (ORCID: https://orcid.org/0000-0002-7730-4577)
- Min Xu (ORCID: https://orcid.org/0000-0001-6654-8878)
- Du Zhu (ORCID: https://orcid.org/0000-0003-3184-2844)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-3332-8128)
- Gen Li (ORCID: https://orcid.org/0000-0001-6857-0235)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-8201-3272)
- Zixin Deng (ORCID: https://orcid.org/0000-0003-0724-3390)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Jiangxi Science and Technology Normal University (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1002/cbdv.202501158
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences