A RANDOMIZED CLINICAL STUDY OF POMEWHITE®: EFFECTS ON ACNE, SKIN MICROBIOTA, AND OXIDATIVE STRESS

This clinical study evaluates the therapeutic potential of POMEWHITE®, a novel pomegranate-derived food supplement, in improving skin health and alleviating acne-related symptoms. Conducted over eight weeks, the trial involved 100 participants with moderate to severe acne and 20 healthy controls. Participants were randomly assigned to placebo (rice powder) or POMEWHITE® supplementation at 150 mg/day or 300 mg/day. Primary outcomes included acne lesion count, bacterial colony composition, and inflammation severity, while secondary outcomes assessed skin brightness, fine lines, antioxidative enzyme activity, and participant satisfaction. Results showed that eight weeks of POMEWHITE® intake, particularly at 300 mg/day, significantly reduced P. acnes colonies and increased beneficial skin flora. There was a notable decrease in lipase activity, contributing to reduced sebum production. Visual analogue scores and dermatologist-graded acne severity scales demonstrated substantial improvements in treated groups compared to placebo. Additionally, POMEWHITE® significantly improved antioxidant defenses by lowering superoxide dismutase (SOD) and increasing glucose-6-phosphate dehydrogenase (G6PD) levels. Inflammatory markers IL-4 and IFN-γ also showed favorable modulation, reflecting reduced skin inflammation. Tyrosinase activity inhibition and improvements in fine lines and wrinkles further highlighted the supplement’s anti-aging and skin-brightening potential. These findings suggest that POMEWHITE® is a safe and effective nutraceutical intervention for acne management. Its ability to restore microbiome balance, reduce oxidative stress and inflammation, and enhance skin appearance positions it as a promising alternative or adjunct to conventional acne therapies.