A cross-sectional, observational study on quality of life in epilepsy patients

• The majority of cases were observed in younger population with a greater prevalence in males compared to females. • The primary risk factors are genetic predispositions, alcoholism, smoking, consanguineous marriages and comorbidities are diabetes and hypertension. • Generalized Tonic Clonic Seizures represented the most common seizure types. • Levetiracetam was administered as a monotherapy in 40.4 % cases, while it was combined with other antiepileptic medications in 59.6 % of cases. • Demographic as well as clinical parameter had significant influence of QOL of patients. The study involved a cross-sectional, observational patient survey using QOLIE-31 to assess relationships between demographic characteristics (age, gender, and residence status) and clinical factors (seizure type, epilepsy duration, comorbid conditions, risk factors, therapy options (monotherapy or polytherapy) on health-related quality of life (QOL) in people with epilepsy. Research data collection includes 260 epilepsy patients who have visited Neurology departments of Khammam region tertiary care hospitals. The QOLIE-31 survey revealed unsatisfactory mean scores in the Seizure Worry (46.05 ± 7.59) and Overall Quality of Life (44.21 ± 8.14) domains and Social Functioning (43.31 ± 9.69) dimensions. All variables along with seizure type and therapy type and disease duration along with gender and age and comorbidities had substantial influence on QOL scores among epilepsy patients. The QOL scores tended to be lower for patients with focal onset aware seizures and received multiple antiseizure medications. In contrast, patients without health conditions who received one anti-seizure medication reported better QOL scores. The statistical results showed that both demographic elements and clinical measurements created significant effects on QOL (ANOVA p < 0.0001). Treating patients with a single drug regimen of levetiracetam resulted in more beneficial treatment outcomes and enhanced quality of life.