Comparison of clinical efficacy and secondary infections between conventional-dose and high-dose glucocorticoid in hemorrhagic fever with renal syndrome: a dual-center retrospective cohort study
High-dose GC show no superiority over conventional-dose GC on hospital stay, acute-phase fluid requirement, renal replacement rates, mechanical ventilation needs, severe hemorrhagic complications, or mortality. High-dose GC may increase secondary infections in HFRS patients with a shock phase. GC therapy ≥ 4 days may also increase secondary infections in patients without a shock phase.
Authors
- Xiaofei Yang (ORCID: https://orcid.org/0000-0002-9847-5009)
- Hong Du (ORCID: https://orcid.org/0000-0002-1107-2902)
- Zhanhu Bi
- Jianqi Lian (ORCID: https://orcid.org/0000-0002-5549-7590)
- Pingping Zhu (ORCID: https://orcid.org/0000-0002-8009-2923)
- Haifeng Hu (ORCID: https://orcid.org/0000-0002-4884-323X)
- Hongkai Xu
- Yanping Li
- Ju Zhan (ORCID: https://orcid.org/0000-0001-8534-0300)
- Ludan Zhang (ORCID: https://orcid.org/0000-0003-3531-6171)
- Fei Hu (ORCID: https://orcid.org/0000-0001-7071-1375)
- Denghui Yu
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- General Hospital of Guangzhou Military Command (CN)
- Command Hospital Air Force (IN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12879-025-11148-2
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fourth Military Medical University