From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase
A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report by Sala et al. describing an RNA duplex-bound state. This structure constitutes a snapshot of the complex in an early elongation step of the RNA synthesis cycle.
Authors
- Max Renner (ORCID: https://orcid.org/0000-0001-9885-8256)
- Rupesh Balaji Jayachandran (ORCID: https://orcid.org/0009-0000-4969-6991)
Institutions
- Umeå University (SE)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.tibs.2025.05.003
- Citations
- 1
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- University of Warwick