Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation
These results suggest that 2-DG ameliorates mechanical allodynia, spontaneous pain and neuroinflammation in the spinal cord of CIBP mice by promoting the transition from the M1 phenotype to the M2 phenotype. This study may provide a novel strategy for the treatment of CIBP.
Authors
- Ya‐Qun Zhou (ORCID: https://orcid.org/0000-0001-6917-4808)
- Wei Mei (ORCID: https://orcid.org/0000-0001-6556-6628)
- Dai-Qiang Liu (ORCID: https://orcid.org/0000-0001-8878-8485)
- Long-Qing Zhang
- Shao‐Jie Gao
- Jiayi Wu (ORCID: https://orcid.org/0000-0002-4819-2190)
- Fan‐He Song
- Danyang Li (ORCID: https://orcid.org/0000-0002-7508-6019)
- Lin Liu (ORCID: https://orcid.org/0009-0006-7198-0589)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Pain
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1177/17448069251348778
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49