Enhanced bactericidal activity of selenosteroid complexes with zinc, copper, and cobalt against resistant bacterial strains
Let's enhance the activity of selenosteroids! For this purpose, we have obtained a new class of metal complexes with the steroid β-hydroxy-phenylselenide as a model ligand using a simple and efficient methodology. The obtained compounds were characterised by <sup>1</sup>H and <sup>77</sup>Se nuclear magnetic resonance spectroscopy, infra-red spectroscopy, mass spectra, X-ray diffraction and thermogravimetric analysis. The bactericidal activity of the complexes against Pseudomonas aeruginosa and Staphylococcus aureus was then evaluated using a standard killing assay. The results showed that the copper and cobalt complexes with selenosteroid exhibited significant bactericidal activity against P. aeruginosa. The presented synthetic method shows potential for obtaining compounds that may be effective in treating infections caused by these clinically relevant bacterial strains.
Authors
- Izabella Jastrzębska (ORCID: https://orcid.org/0000-0003-3268-3515)
- Marta Malinowska (ORCID: https://orcid.org/0000-0002-2803-1381)
- Sławomir Wojtulewski (ORCID: https://orcid.org/0000-0001-5535-4525)
- Urszula Wnorowska (ORCID: https://orcid.org/0000-0002-0410-3475)
- Karolina H. Markiewicz (ORCID: https://orcid.org/0000-0002-4857-0489)
- B. Kalska-Szostko (ORCID: https://orcid.org/0000-0002-6353-243X)
- Joanna Wysocka (ORCID: https://orcid.org/0000-0002-8016-9521)
- Robert Bucki (ORCID: https://orcid.org/0000-0001-7664-9226)
- Damian Zarzecki
Institutions
- Medical University of Białystok (PL)
- University of Białystok (PL)
- Jastrzębska Spółka Węglowa (Poland) (PL)
- University of Silesia in Katowice (PL)
Publication Details
- Journal
- The Journal of Steroid Biochemistry and Molecular Biology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.jsbmb.2025.106793
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission