Association of Blood Lipoprotein Levels With Incident Alzheimer Disease in Community-Dwelling Individuals
Lower sdLDL-C and higher ApoB48 concentrations were associated with a lower AD risk. In addition, individuals with the lowest HDL-C concentrations were less likely to develop AD compared with the remaining sample. These findings underscore links between lipoprotein metabolism pathways and AD risk, emphasizing the potential role of blood lipoprotein markers in AD risk stratification and of lipid modification strategies in dementia prevention.
Authors
- Ramachandran Srini Vasan (ORCID: https://orcid.org/0000-0001-7357-5970)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Sophia Francesca DP Lu (ORCID: https://orcid.org/0000-0002-2002-9818)
- Jesús D. Melgarejo (ORCID: https://orcid.org/0000-0002-1382-1153)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Sokratis Charisis (ORCID: https://orcid.org/0000-0001-6578-393X)
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
Institutions
- Boston University (US)
- The University of Texas Rio Grande Valley (US)
- Institute for Neurodegenerative Disorders (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1212/wnl.0000000000213715
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16