Epidermal IL-36 and CCL17 Protein Expression Distinguish Palmar Eczema from Palmar Psoriasis
The diagnosis of atopic dermatitis (AD) and psoriasis (Pso) is primarily based on clinical morphology and lesion distribution patterns. However, even experienced physicians have difficulties distinguishing between eczema and psoriasis, particularly in certain areas such as outer ear canal or palmoplantar regions. In this study we have focussed on palmar skin manifestations. Although histopathology is considered state of the art for diagnosis, it has limitations. This is especially true for hyperkeratotic rhagadiform palmoplantar presentations and superinfected eczema, as they can resemble psoriasiform changes in histology(An, 2020, Politiek, 2020).
Authors
- Martin Stacey (ORCID: https://orcid.org/0000-0003-3502-5542)
- Johannes Pawlowski
- Detlef Becker (ORCID: https://orcid.org/0000-0003-1679-3095)
- Isabel Hyde
- Gregor Ojak (ORCID: https://orcid.org/0009-0000-1675-186X)
- Joanna Wegner (ORCID: https://orcid.org/0000-0002-7710-9675)
- Miriam Wittmann (ORCID: https://orcid.org/0000-0003-2328-4926)
- Stefan Tenzer (ORCID: https://orcid.org/0000-0003-3034-0017)
- Caroline Mann (ORCID: https://orcid.org/0000-0001-7044-2216)
- Janina Beczinski
Institutions
- University of Leeds (GB)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Helmholtz Institute Mainz (DE)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
Publication Details
- Journal
- Journal of Investigative Dermatology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.jid.2025.04.040
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Psoriasis Association