Neutrophil extracellular traps activate STING signaling to promote dendritic cell-driven rejection after liver transplantation
We found that NETs can regulate dendritic cell maturation through STING-related pathways after liver transplantation, which may ultimately promote the occurrence of liver transplant rejection, providing a new perspective for clinical diagnosis, treatment and prevention of liver transplant rejection.
Authors
- R Zhang (ORCID: https://orcid.org/0009-0008-6365-565X)
- Shipeng Li (ORCID: https://orcid.org/0000-0001-8615-2440)
- Dongdong Wu (ORCID: https://orcid.org/0000-0001-6739-8437)
- Yizhang Chen (ORCID: https://orcid.org/0000-0003-3873-4352)
- Jie Yin (ORCID: https://orcid.org/0000-0003-1852-1042)
- Yan Wang (ORCID: https://orcid.org/0000-0001-7764-8233)
- Wei Wang (ORCID: https://orcid.org/0000-0002-6179-4188)
- Jun Xu (ORCID: https://orcid.org/0000-0003-3755-9660)
- Cilong Yu (ORCID: https://orcid.org/0000-0002-6683-381X)
- Qi Han (ORCID: https://orcid.org/0000-0001-6279-8992)
Institutions
- Shanxi Medical University (CN)
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- First Hospital of Shanxi Medical University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.intimp.2025.114763
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Health Commission of Shanxi Province
- National Natural Science Foundation of China
- Natural Science Foundation of Shanxi Province
- ShanXi Science and Technology Department
- Shanxi Provincial Key Research and Development Project