Clinical and Genomic Landscape of FGFR3 Alterations Across Different Stages of Urothelial Cancer
We analyzed a protein called fibroblast growth factor receptor 3 (FGFR3) in patients with cancer of the urinary tract. We found that more aggressive tumors had fewer genetic changes in FGFR3 in comparison to less aggressive tumors. However, genetic changes in FGFR3 were not related to survival for these patients.
Authors
- Maximilian Haas (ORCID: https://orcid.org/0000-0003-3132-0130)
- Philipp Erben (ORCID: https://orcid.org/0000-0002-8279-7636)
- Bernd Wullich (ORCID: https://orcid.org/0000-0002-0665-6604)
- Roman Mayr (ORCID: https://orcid.org/0000-0003-1796-3260)
- Johannes Breyer (ORCID: https://orcid.org/0000-0003-0674-4150)
- Christian Bolenz (ORCID: https://orcid.org/0000-0002-6171-6040)
- Ralph M. Wirtz (ORCID: https://orcid.org/0000-0001-9054-8579)
- Florian Roghmann
- Niklas Klümper (ORCID: https://orcid.org/0000-0002-3258-0586)
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Danijel Sikic (ORCID: https://orcid.org/0000-0002-6588-3022)
- Robert Stöhr (ORCID: https://orcid.org/0000-0002-1468-2554)
- Arndt Hartmann
- Veronika Bahlinger
- Maximilian Burger (ORCID: https://orcid.org/0009-0005-5013-9435)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Ulm (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Erlangen (DE)
- University Children's Hospital Tübingen (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Hospital Ulm (DE)
- University Medical Centre Mannheim (DE)
- University of Regensburg (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.euros.2025.04.005
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02