The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome
Our study suggests that SMPDL3b may be a key modulator of proteinuria and podocyte integrity in Alport Syndrome, decoupling proteinuria from kidney failure, and suggests that improvement of glomerular structure and function may not always translate into protection from chronic kidney disease progression.
Authors
- Shamroop Kumar Mallela (ORCID: https://orcid.org/0000-0002-4553-8504)
- Rachel Njeim (ORCID: https://orcid.org/0009-0000-0501-395X)
- Darren A. Yuen (ORCID: https://orcid.org/0000-0002-0054-6607)
- Judith Molina
- Matthew Tolerico (ORCID: https://orcid.org/0000-0002-1891-1166)
- Luisa Ulloa Severino
- Alexis Sloan
- Maria Boulina
- Laura Perin (ORCID: https://orcid.org/0000-0002-6955-6416)
- Yiqin Zuo (ORCID: https://orcid.org/0000-0002-7287-0350)
- Wadih Issa (ORCID: https://orcid.org/0000-0002-3239-9875)
- Maria Ficarella
- Antonio Miguel Fontanella (ORCID: https://orcid.org/0000-0003-2178-0870)
- Sandra Merscher (ORCID: https://orcid.org/0000-0002-4757-7494)
- Guanshi Zhang (ORCID: https://orcid.org/0000-0001-6557-4521)
- Alla Mitrofanova (ORCID: https://orcid.org/0000-0001-5065-9522)
- George W. Burke (ORCID: https://orcid.org/0000-0002-6888-2842)
- Kumar Sharma (ORCID: https://orcid.org/0000-0002-7550-8525)
- Jin‐Ju Kim (ORCID: https://orcid.org/0000-0001-8432-7956)
- Veronika Semenova
- Alessia Fornoni
- Arianna Carrazco
- Javier Varona Santos J
Institutions
- Children's Hospital of Los Angeles (US)
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- Toronto Public Health (CA)
- University of Toronto (CA)
- Miami Transplant Institute (US)
Publication Details
- Journal
- Kidney International
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.kint.2025.04.024
- Citations
- 4
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 5.72