Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice
Prenatal IPA is transferred to the fetus and promotes gut development, conferring long-term protection against colitis in MIA offspring. These findings underscore the enduring impact of maternal interventions on offspring intestinal health.
Authors
- B. Bao
- Yuanbin She (ORCID: https://orcid.org/0000-0002-1007-1852)
- Rui Guo (ORCID: https://orcid.org/0000-0002-8234-9817)
- Duo Yun (ORCID: https://orcid.org/0000-0001-7999-5626)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-0804-6404)
- Yang Liu (ORCID: https://orcid.org/0000-0003-4259-8875)
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-6863-6561)
- Xia Chen (ORCID: https://orcid.org/0000-0003-3732-073X)
- Ying He (ORCID: https://orcid.org/0009-0002-3615-4098)
- Chen Ding (ORCID: https://orcid.org/0000-0002-3228-8585)
Institutions
- North West Agriculture and Forestry University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.jare.2025.05.051
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61