Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway

Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies. Icariin (ICA), a natural compound derived from Epimedium, has been demonstrated exhibiting anti-inflammatory and anti-oxidant, but its impact on diabetic cataracts remains elusive. In this study, we used both <i>in vitro</i> SRA01/04 cells and <i>in vivo</i> SD rats' model to explored the protective effects of ICA in cataract formation. Following network pharmacology, proteomic and surface plasmon resonance (SPR) analyses further demonstrated that ICA interacts with insulin-like growth factor-binding protein-3 (IGFBP3) and modulates oxidative stress as well as apoptosis via the PI3K/AKT signaling pathway. These findings collectively demonstrated that ICA could alleviate high glucose-induced oxidative stress and cell apoptosis <i>in vitro</i> and <i>in vivo</i>, suggesting that ICA is a potent natural compound with protective effects in DC, offering an effective therapeutic approach for the disease management.

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Publication Details

Journal
iScience
Published
2025-05-30
DOI
https://doi.org/10.1016/j.isci.2025.112796
Citations
1
Primary Topic
Natural product bioactivities and synthesis
Type
article
Field-Weighted Citation Impact
0.81

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article

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway

Xiang Gao, Hangjia Zuo, Shuhao Zeng, Shangze Gao et al.
1 citations
iScience
Natural product bioactivities and synthesis
0.81
article

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway

Xiang Gao, Hangjia Zuo, Shuhao Zeng, Shangze Gao, Fanfan Huang, Shengping Hou, Shijie Zheng, Tian Meng, Xianyang Liu, Chao Wu, Yakun Wang, Ke Hu, Fan Cao, Hui Yang, Wenxian Yang, Baorui Chu, Yongguo Xiang, Hui Feng, Wenjuan Wan
article en
1 citations

Abstract

Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies. Icariin (ICA), a natural compound derived from Epimedium, has been demonstrated exhibiting anti-inflammatory and anti-oxidant, but its impact on diabetic cataracts remains elusive. In this study, we used both <i>in vitro</i> SRA01/04 cells and <i>in vivo</i> SD rats' model to explored the protective effects of ICA in cataract formation. Following network pharmacology, proteomic and surface plasmon resonance (SPR) analyses further demonstrated that ICA interacts with insulin-like growth factor-binding protein-3 (IGFBP3) and modulates oxidative stress as well as apoptosis via the PI3K/AKT signaling pathway. These findings collectively demonstrated that ICA could alleviate high glucose-induced oxidative stress and cell apoptosis <i>in vitro</i> and <i>in vivo</i>, suggesting that ICA is a potent natural compound with protective effects in DC, offering an effective therapeutic approach for the disease management.

iScienceVol. 28(7)
Beijing Tongren Hospital (CN), Capital Medical University (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
National Natural Science Foundation of China
Zero hunger
Openalex Percentile: Top 27%
Natural product bioactivities and synthesis
0.81
DOIOpen Access PDFOpenAlex
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