Rapid Metagenomic Sequencing of Bronchoalveolar Lavage Fluid for Diagnosis of Infection in Patients With Hematologic Malignancies and Pulmonary Complications
Culture-independent sequencing approaches had modest agreement with CMT when considering bacterial PCs and showed poor detection of fungal pathogens. Sequencing frequently identified additional plausible respiratory pathogens, and further validation is needed to determine if such detection represents clinically missed infections or nonpathogenic colonization.
Authors
- Charles S. Dela Cruz (ORCID: https://orcid.org/0000-0002-5258-1797)
- Khaled Sayed (ORCID: https://orcid.org/0000-0002-1252-3170)
- Sawa Ito (ORCID: https://orcid.org/0000-0002-6076-0234)
- Panayiotis V. Benos (ORCID: https://orcid.org/0000-0003-3172-3132)
- Ghady Haidar (ORCID: https://orcid.org/0000-0003-0634-8211)
- Georgios D. Kitsios (ORCID: https://orcid.org/0000-0002-1018-948X)
- Emily Geramita (ORCID: https://orcid.org/0000-0001-6387-4950)
- Barbara A. Methé (ORCID: https://orcid.org/0000-0001-8711-1448)
- Warren D. Shlomchik
- Annie Im
- Xiaohong Wang (ORCID: https://orcid.org/0000-0002-5756-8460)
- Alison Morris
- M. Max Hensley
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- CHEST Pulmonary
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.chpulm.2025.100173
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Association for the Study of Lung Cancer
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Shadyside Hospital Foundation
- NHLBI Division of Intramural Research