Primary spinal cord astroblastoma: a case report and systematic review of the literature detailing management and understanding histopathological, epigenetic, and molecular analysis

With the present report of a patient whose tumor exhibited EWSR1::BEND2 fusion, there are now 12 total reports in the literature of primary spinal AB. These cases span various pathological and molecular testing results, treatment strategies, and clinical courses. Given the diversity of current molecular signatures of spinal AB, this summative assessment of the current literature offers insights to inform guidelines for classifying AB and developing evidence-based treatment strategies going forward.