Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition
This study is the first to elucidate that MLT synergistically ameliorates mitochondrial dysfunction through dual mechanisms-activating the NRF2 antioxidant pathway and suppressing OPA1-mediated mitochondrial fusion-providing novel therapeutic targets for AS.
Authors
- Chengbo Lu (ORCID: https://orcid.org/0009-0007-6921-5025)
- Quan Lin (ORCID: https://orcid.org/0000-0003-3693-9311)
- Xiaoli Guo (ORCID: https://orcid.org/0000-0002-6346-1846)
- Han Zhou (ORCID: https://orcid.org/0000-0001-5264-8202)
- T. Luo
- Zijun Cai (ORCID: https://orcid.org/0000-0002-5404-7862)
- Weiqun Wang (ORCID: https://orcid.org/0000-0002-1295-8246)
- Chaonan Peng
- Guangyuan Yang
Institutions
- Jiamusi University (CN)
- Harbin Medical University (CN)
- First Affiliated Hospital of Jiamusi University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.intimp.2025.114960
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00