A case of Hyperkalemia-induced Brugada Phenocopy: a rare but serious electrocardiographic imposter

Brugada Syndrome is a potentially fatal, hereditary cardiac disorder that may precipitate sudden cardiac death if not identified. An electrocardiogram (ECG) revealing a characteristic coved ST segment elevation followed by negative T wave in a right-sided precordial lead is pathognomonic for the Brugada pattern. Recently it has been shown that certain abnormalities, such as an electrolyte disturbance, may precipitate a Brugada pattern on ECG. Once the precipitating factor is treated, the rhythm reverts to baseline, coining the term Brugada Phenocopy. Here we present a captivating case of a 40-year-old female who was found unresponsive and determined to have a Brugada pattern on ECG secondary to hyperkalemia. Once appropriately treated, ECG reverts to normal baseline.

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Publication Details

Journal
Oxford Medical Case Reports
Published
2025-05-01
DOI
https://doi.org/10.1093/omcr/omaf036
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
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A case of Hyperkalemia-induced Brugada Phenocopy: a rare but serious electrocardiographic imposter

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Oxford Medical Case Reports
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article

A case of Hyperkalemia-induced Brugada Phenocopy: a rare but serious electrocardiographic imposter

Yezin Shamoon, Abraam Rezkalla, Moath Hattab, Fathi Milhem, Islam Rajab, Fayez Shamoon
article en

Abstract

Brugada Syndrome is a potentially fatal, hereditary cardiac disorder that may precipitate sudden cardiac death if not identified. An electrocardiogram (ECG) revealing a characteristic coved ST segment elevation followed by negative T wave in a right-sided precordial lead is pathognomonic for the Brugada pattern. Recently it has been shown that certain abnormalities, such as an electrolyte disturbance, may precipitate a Brugada pattern on ECG. Once the precipitating factor is treated, the rhythm reverts to baseline, coining the term Brugada Phenocopy. Here we present a captivating case of a 40-year-old female who was found unresponsive and determined to have a Brugada pattern on ECG secondary to hyperkalemia. Once appropriately treated, ECG reverts to normal baseline.

Oxford Medical Case ReportsVol. 2025(5)
An-Najah National University (PS), St. Joseph’s University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 78%
Cardiac electrophysiology and arrhythmias
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