Pre-treatment lysis time of plasma-derived fibrin clots and bleeding in patients on oral anticoagulants for atrial fibrillation in the ARISTOTLE trial
Shorter pre-treatment fibrin clot lysis time independently predicted higher bleeding risk in patients receiving oral anticoagulation for AF.
Authors
- Christopher Bull Granger (ORCID: https://orcid.org/0000-0002-0045-3291)
- Johan Westerbergh (ORCID: https://orcid.org/0000-0003-1076-6045)
- Agneta Siegbahn (ORCID: https://orcid.org/0000-0003-3955-5671)
- Thomas A. Nelson
- Robert F. Storey (ORCID: https://orcid.org/0000-0002-6677-6229)
- Heather M. Judge
- Lars Wallentin (ORCID: https://orcid.org/0000-0003-0378-6531)
- Renato D. Lópes (ORCID: https://orcid.org/0000-0003-2999-4961)
- John Hunter Alexander (ORCID: https://orcid.org/0000-0002-1444-2462)
- Elaine M. Hylek (ORCID: https://orcid.org/0000-0001-8263-8304)
- William A. Parker (ORCID: https://orcid.org/0000-0002-7822-8852)
- Ramzi Ajjan (ORCID: https://orcid.org/0000-0002-1636-3725)
- Christina Christersson (ORCID: https://orcid.org/0000-0001-9116-8084)
- Justin Lee (ORCID: https://orcid.org/0000-0003-2444-0169)
Institutions
- Boston University (US)
- Uppsala University (SE)
- University of Leeds (GB)
- Duke University (US)
- Clinical Research Institute (US)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Leeds Dental Hospital (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1093/eurheartj/ehaf347
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- AtriCure
- Bayer Corporation
- CSL Behring
- Boston Scientific Corporation
- CryoLife
- Abiomed
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- Novo Nordisk
- Idorsia Pharmaceuticals
- CytoSorbents Europe
- National Institutes of Health
- U.S. Food and Drug Administration
- Abbott Diabetes Care
- NIHR Sheffield Biomedical Research Centre
- Daiichi Sankyo Europe