Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro
Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1-34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1-3, 6, 8, 10, 14, 17-19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.
Authors
- Yun Zhao (ORCID: https://orcid.org/0000-0001-9136-2442)
- Yunli Zhao (ORCID: https://orcid.org/0000-0002-4775-2811)
- Xiao‐Dong Luo
- Changbin Wang (ORCID: https://orcid.org/0000-0003-2480-6116)
- Bang-Yin Tan
- Z Wang (ORCID: https://orcid.org/0000-0002-5634-0755)
Institutions
- Kunming Institute of Botany (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1007/s13659-025-00516-9
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Institute of Botany, Chinese Academy of Sciences
- Major Science and Technology Projects in Yunnan Province