An <i>ex vivo</i> model to determine transmembrane clearance of antimicrobials during continuous renal replacement therapy
These ex vivo methods can be combined with patient pharmacokinetic data to determine optimal drug dosing regimens for CRRT during new drug development.
Authors
- Christina Koenig (ORCID: https://orcid.org/0000-0002-3354-3496)
- Hanna Roenfanz
- Joseph L. Kuti (ORCID: https://orcid.org/0000-0002-4464-3126)
- David P. Nicolau (ORCID: https://orcid.org/0000-0002-4148-0165)
- Yuwei Shen (ORCID: https://orcid.org/0009-0003-2542-386X)
- C McGrath
Institutions
- Hartford Hospital (US)
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Hartford Financial Services (United States)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1093/jac/dkaf177
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- U.S. Food and Drug Administration