Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naïve glioblastoma
Corticosteroid administration can induce a significant "pseudoresponse" in glioblastoma, with an observed reduction in contrast-enhancing tumor volume of 23.7% and a time interval adjusted reduction of 44.0% (25.7%-62.2%), and an ADC drop of 180 × 10-6 mm2/s (14.2%). These data confirm that radiographic measurements are impacted by corticosteroids and provide benchmarks for the development of adjusted response criteria accounting for corticosteroid use.
Authors
- David A. Nathanson (ORCID: https://orcid.org/0000-0002-4919-9159)
- Noriko Salamon (ORCID: https://orcid.org/0000-0002-3520-9467)
- Richard G. Everson (ORCID: https://orcid.org/0000-0003-2809-3061)
- Benjamin M. Ellingson (ORCID: https://orcid.org/0000-0002-2764-6640)
- Jingwen Yao (ORCID: https://orcid.org/0000-0002-8828-1841)
- Phioanh Leia Nghiemphu (ORCID: https://orcid.org/0000-0003-4064-6079)
- Francesco Sanvito (ORCID: https://orcid.org/0000-0003-3379-9958)
- Albert Lai (ORCID: https://orcid.org/0000-0002-7265-2986)
- Timothy F. Cloughesy (ORCID: https://orcid.org/0000-0002-8656-7483)
- Catalina Raymond (ORCID: https://orcid.org/0000-0003-2757-439X)
- Ashley Teraishi (ORCID: https://orcid.org/0009-0004-3442-8109)
- Robert Chong
- Asher Kim (ORCID: https://orcid.org/0009-0008-5471-5462)
Institutions
- University of California, Los Angeles (US)
- Samueli Institute (US)
- Imaging Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1093/neuonc/noaf136
- Citations
- 4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.50