Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors
Our results demonstrate that IPS is a generalizable multiomic biomarker that can be widely used clinically as a prognosticator of ICI-based regimens.
Authors
- Rossin Erbe (ORCID: https://orcid.org/0000-0002-3423-2104)
- Ezra E.W. Cohen (ORCID: https://orcid.org/0000-0002-9872-6242)
- Chithra Sangli
- Mario G. Rosasco
- A. Kate Sasser
- Brett Mahon (ORCID: https://orcid.org/0000-0002-0024-0464)
- Ben Terdich
- Matthew R. Zibelman (ORCID: https://orcid.org/0000-0003-1475-6477)
- Halla Nimeiri (ORCID: https://orcid.org/0000-0002-8760-6456)
- Douglas R. Adkins (ORCID: https://orcid.org/0000-0003-3207-8227)
- Sandip Pravin Patel (ORCID: https://orcid.org/0000-0002-8387-4840)
- Subhadip Mukhopadhyay (ORCID: https://orcid.org/0000-0002-7025-8694)
- Michelle M. Stein (ORCID: https://orcid.org/0000-0002-7680-9012)
- Alia Zander (ORCID: https://orcid.org/0000-0001-7211-9391)
- Timothy A. Chan (ORCID: https://orcid.org/0000-0002-9265-0283)
- Justin Guinney (ORCID: https://orcid.org/0000-0003-1477-1888)
- Timothy Taxter (ORCID: https://orcid.org/0000-0001-6489-1007)
- Kyle A. Beauchamp (ORCID: https://orcid.org/0000-0001-6095-8788)
- Michelle Ting-Lin
- Yan Liu (ORCID: https://orcid.org/0000-0003-4242-4840)
- Ailin Jin
- Seung Won Hyun
- N. M. Patel
Institutions
- Fox Chase Cancer Center (US)
- Cleveland Clinic (US)
- Washington University in St. Louis (US)
- Tempus Labs (United States) (US)
- Moores Cancer Center
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-011363
- Citations
- 10
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 10.45