Dechlorinative Pyrazinylation of Glycine Derivatives
Amino acids and pyrazines both play crucial roles in drug design. Here, we present a visible-light-driven, redox-neutral α-C(sp<sup>3</sup>)-H pyrazinylation of glycine derivatives with chloropyrazines, enabling the efficient synthesis of α-pyrazinyl glycine derivatives with valuable biological and pharmaceutical potential.
Authors
- Youwan Ye
- Xiaolong Zhao (ORCID: https://orcid.org/0000-0001-7104-8309)
- Congde Huo (ORCID: https://orcid.org/0000-0002-3374-7931)
- Xiazhen Bao (ORCID: https://orcid.org/0000-0003-4658-4227)
- Delin Guan
- Peiqin Zhang
Institutions
- Ministry of Education (BD)
- Northwest Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1021/acs.orglett.5c01599
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China