NAD+/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress
We identified that NAD<sup>+</sup>/Nrf2 signaling regulated oxidative level and thus promoted osteogenic commitment of BMSCs under cyclic stretch stress. Targeting NAD<sup>+</sup> metabolism or administrating exogenous supplementation to promote bone rebuilding could be a prospective therapy to accelerate OTM.
Authors
- Fulan Wei (ORCID: https://orcid.org/0000-0001-6827-8293)
- Huiying Ren (ORCID: https://orcid.org/0000-0002-5545-5470)
- Jixiao Wang (ORCID: https://orcid.org/0000-0002-5027-2456)
- Lingyun Wang (ORCID: https://orcid.org/0000-0001-5583-2822)
- Zijie Zhang (ORCID: https://orcid.org/0000-0002-4900-506X)
- Jiani Liu (ORCID: https://orcid.org/0000-0001-5669-0221)
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Progress in Orthodontics
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s40510-025-00566-2
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- National Natural Science Foundation of China