Metformin for the Prevention of Hyperemesis Gravidarum: An Observational Cohort Study
This cohort study found a lower rate of HG in the preconceptional metformin-exposed group compared to unexposed, although the study was not powered to identify a significant association. Rated and durations NVP were similar between groups. These are relevant to guiding future clinical trials on the efficacy of metformin as a prophylactic agent for HG.
Authors
- Christina Chambers (ORCID: https://orcid.org/0000-0003-4675-7722)
- Michael Ceulemans (ORCID: https://orcid.org/0000-0002-4130-5869)
- Yunjun Luo
- Laure Sillis (ORCID: https://orcid.org/0000-0002-7545-2357)
- Essi Heinonen (ORCID: https://orcid.org/0000-0003-2107-0561)
- Diana Johnson
Institutions
- Research Foundation - Flanders (BE)
- Karolinska Institutet (SE)
- University of California San Diego (US)
- KU Leuven (BE)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1111/1471-0528.18238
- Citations
- 4
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 7.51