SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program
Stage 4S-specific tumor cell subpopulation exhibits a spontaneous regression-like program, from which SLIT3 mediates intratumoral crosstalk and promotes neuroblastoma differentiation via PLCβ/PKC signaling. These findings provide new insights into the mechanism of spontaneous regression in neuroblastoma and offer novel therapeutic targets for differentiation-based treatment strategies.
Authors
- Jie Lei (ORCID: https://orcid.org/0000-0002-3429-4436)
- Bin He (ORCID: https://orcid.org/0000-0001-8019-8480)
- Dekang Lv
- Deshun Zeng
- Luoxuan Wang
- Bing Deng
- Quentin Liu (ORCID: https://orcid.org/0000-0002-0999-9805)
- Fang Liu (ORCID: https://orcid.org/0000-0002-8325-1213)
- Meiling Liu (ORCID: https://orcid.org/0000-0002-1506-1143)
- Zifeng Wang (ORCID: https://orcid.org/0000-0001-7400-5224)
- Shulan Wang (ORCID: https://orcid.org/0000-0002-1413-8022)
- Yi Wu (ORCID: https://orcid.org/0000-0003-2726-6135)
- Wenjing Yan (ORCID: https://orcid.org/0000-0001-7115-4486)
- Min Yan (ORCID: https://orcid.org/0000-0001-9922-5469)
Institutions
- Sun Yat-sen University (CN)
- Dalian Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12967-025-06621-0
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Cancerfonden
- Natural Science Foundation of Guangdong Province
- Science Fund for Creative Research Groups
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Shenzhen Bay Laboratory
- Sun Yat-sen University Cancer Center