[18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics
This is the first clinical evaluation of [<sup>18</sup>F]SiTATE-PET/CT in patients with PPGL. MTV and TLU measured with [<sup>18</sup>F]SiTATE-PET/CT correlated well with the tumor marker chromogranin A in serum and with (nor)metanephrines in urine and plasma. Within the limits imposed by the small cohort, our results suggest that TLU and MTV in [<sup>18</sup>F]SiTATE-PET/CT could be used as SSTR imaging biomarker for monitoring of disease progression and secretory activity in patients with PPGL.
Authors
- Thomas Pfluger
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- Christoph Josef Auernhammer (ORCID: https://orcid.org/0000-0001-8087-3722)
- Júnia Ribeiro de Oliveira Longo Schweizer (ORCID: https://orcid.org/0000-0002-8050-9127)
- Christine Schmid‐Tannwald (ORCID: https://orcid.org/0000-0002-7304-6961)
- Christian Lottspeich (ORCID: https://orcid.org/0000-0002-1770-4392)
- Rudolf Alexander Werner (ORCID: https://orcid.org/0000-0003-3372-6046)
- Alessa Fischer (ORCID: https://orcid.org/0000-0003-4555-8334)
- Matthias Kroiß (ORCID: https://orcid.org/0000-0002-7628-3161)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Friederike Völter (ORCID: https://orcid.org/0000-0001-6157-0363)
- Katharina Wang (ORCID: https://orcid.org/0000-0002-7795-1395)
- Martin Bidlingmaier (ORCID: https://orcid.org/0000-0002-4681-6668)
- Nabeel Mansour (ORCID: https://orcid.org/0000-0002-3467-1916)
- Matthias K. Auer (ORCID: https://orcid.org/0000-0001-7153-8332)
- Svenja Nölting (ORCID: https://orcid.org/0000-0002-7064-590X)
- Till Braunschweig (ORCID: https://orcid.org/0000-0001-9166-2912)
- Alena Gesenhues
- Sean Ira G. Gacula
- Simon Lindner (ORCID: https://orcid.org/0009-0007-4379-4436)
- Meike Onkes
- Paul Dahlmann
- Isabel Stüfchen
- Franz‐Josef Gildehaus
Institutions
- German Cancer Research Center (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- University Hospital of Zurich (CH)
- Munich Cluster for Systems Neurology (DE)
- National Kidney and Transplant Institute (PH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1007/s00259-025-07341-9
- Citations
- 1
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Deutsche Forschungsgemeinschaft