BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH
Our findings indicate that Osbpl8 derived from EVs secreted by anti-inflammatory BMDMs plays important roles in intercellular communication between macrophages and hepatocytes, revealing a novel regulatory mechanism of macrophage homoeostasis in MASH.
Authors
- Yingfu Jiao (ORCID: https://orcid.org/0000-0002-4548-1819)
- Chenchen Ma (ORCID: https://orcid.org/0009-0009-9979-8617)
- Cai–Yang Chen
- Kangjie Xie
- Xihui Wang (ORCID: https://orcid.org/0000-0003-3684-3571)
- Zhangxiang Huang
- Yi Chen (ORCID: https://orcid.org/0000-0002-5180-3490)
- Weifeng Yu (ORCID: https://orcid.org/0000-0002-6408-2338)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Renji Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s10020-025-01275-6
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Fundamental Research Funds for the Central Universities