Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation
The study provides a comprehensive molecular framework demonstrating JUN as a key molecule in hMSC osteogenic differentiation. Deer antler's bioactive compounds, particularly Retinol and Progesterone, potentially exert therapeutic effects through targeted JUN modulation, offering novel insights into natural compound-mediated bone regenerative mechanisms.
Authors
- Xiumao Li
- Haiping Hao (ORCID: https://orcid.org/0000-0003-2522-7546)
- Yinan Wu
- Hanxu Huang
- Chengcheng Yu (ORCID: https://orcid.org/0000-0003-3595-0017)
- Ruofu Tang
- Yuanqing Shen
- Fangcai Li (ORCID: https://orcid.org/0000-0002-2402-781X)
- Zhan Wang (ORCID: https://orcid.org/0000-0002-5791-1097)
- Donghua Huang
- Jingkai Wang (ORCID: https://orcid.org/0000-0003-4905-3595)
- Lifeng Jiang (ORCID: https://orcid.org/0000-0001-9552-5616)
Institutions
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1550249
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Traditional Chinese Medicine Administration