Decoding a novel non-enzymatic protein acetylation mechanism in sperm that is essential for fertilizing potential
This study provides novel evidence for the occurrence of non-enzymatic acetylation in sperm, linked to the modulation of α-tubulin acetylation levels and motility during capacitation. Additionally, it suggests that acetyltransferase activity may play a crucial role in regulating intracellular and acrosomal pH levels in capacitated sperm, facilitating the AR.
Authors
- Darío Krapf (ORCID: https://orcid.org/0000-0001-7607-1954)
- María Iniesta‐Cuerda (ORCID: https://orcid.org/0000-0002-2802-1925)
- Jan Nevoral (ORCID: https://orcid.org/0000-0002-2048-7325)
- Marc Yeste (ORCID: https://orcid.org/0000-0002-2209-340X)
- Julián Garde
- Ana Josefa Soler-Valls
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Charles University (CZ)
- Universitat de Girona (ES)
- National University of Rosario (AR)
- Clínica Girona (ES)
- Hospital General Universitario de Albacete (ES)
- Instituto de Biología Molecular y Celular de Rosario (AR)
Publication Details
- Journal
- Biological Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s40659-025-00613-6
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Generalitat de Catalunya
- Ministerio de Economía y Competitividad
- Institució Catalana de Recerca i Estudis Avançats