Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration
These findings highlight MAPK1 as a pivotal regulator of cellular senescence and immune cell infiltration in IVDD pathogenesis, offering novel therapeutic targets for intervention.
Authors
- Da He (ORCID: https://orcid.org/0009-0005-2162-6197)
- Juan Xia (ORCID: https://orcid.org/0000-0002-4966-7119)
- Ye Wang (ORCID: https://orcid.org/0000-0002-5675-2733)
- Lei Miao (ORCID: https://orcid.org/0009-0004-1647-1445)
- Jiayuan Wu (ORCID: https://orcid.org/0000-0002-4626-2773)
- Hao Li (ORCID: https://orcid.org/0009-0008-2573-8032)
Institutions
- Capital Medical University (CN)
- Guangdong University of Foreign Studies (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1589849
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00