Effects of regular, glulisine, and aspart insulin on vascular endothelial growth factor and angiotensinogen expression in hyperglycemic retinal pigment epithelial (RPE) and human retinal endothelial cells (HRECs)
These findings highlight the differential biological effects of insulin analogues and suggest that aspart insulin, in particular, may offer therapeutic benefits beyond glycemic control by modulating both VEGF-A and RAS-related pathways. Tailored insulin therapies could represent innovative strategies for managing or slowing the progression of diabetic retinopathy.
Authors
- Fatemeh Sanie‐Jahromi (ORCID: https://orcid.org/0000-0001-9508-2632)
- M. Hossein Nowroozzadeh (ORCID: https://orcid.org/0000-0002-7412-1900)
- Habib Hadianfard (ORCID: https://orcid.org/0000-0002-1728-632X)
- Alireza Khosravi (ORCID: https://orcid.org/0000-0003-0736-2090)
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Ophthalmology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fopht.2025.1570232
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71