Radiotherapy Drives Cancer Metastasis through Induction of Amphiregulin

Major Finding: Radiotherapy-induced amphiregulin in solid tumors drives the progression of distant metastases.Concept: Amphiregulin induces an immunosuppressive phenotype in EGFR-expressing mononuclear phagocytes. Impact: Blockade of amphiregulin may enhance the efficacy of radiotherapy in patients with metastatic tumors.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-048
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Radiotherapy Drives Cancer Metastasis through Induction of Amphiregulin

Cancer Discovery
Lung Cancer Research Studies
article

Radiotherapy Drives Cancer Metastasis through Induction of Amphiregulin

article en

Abstract

Major Finding: Radiotherapy-induced amphiregulin in solid tumors drives the progression of distant metastases.Concept: Amphiregulin induces an immunosuppressive phenotype in EGFR-expressing mononuclear phagocytes. Impact: Blockade of amphiregulin may enhance the efficacy of radiotherapy in patients with metastatic tumors.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 81%
Lung Cancer Research Studies
DOISourceOpenAlex
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Radiotherapy Drives Cancer Metastasis through Induction of Amphiregulin · Cancer Discovery (2025) | TGRS Research Map | TGRS