TFRC promotes the proliferation, migration, and invasion of osteosarcoma cells by increasing the intracellular iron content and RRM2 expression
OS cells regulate proliferation, migration, and invasion by overexpressing <i>TFRC</i>, which increases the transport of iron into cells and increases the expression and activity of <i>RRM2</i>.
Authors
- Qifeng Yang (ORCID: https://orcid.org/0000-0003-0576-8513)
- Guoqing Ren (ORCID: https://orcid.org/0000-0002-0278-0018)
- Yong Su (ORCID: https://orcid.org/0000-0002-5225-2790)
- Jian Zhou (ORCID: https://orcid.org/0000-0001-6443-2644)
- Jianmin Li (ORCID: https://orcid.org/0009-0001-8966-4203)
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fonc.2025.1567216
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Shandong University
- Qilu Hospital of Shandong University