Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2
Taken together, we demonstrate that high trypsin levels are associated with a positive pregnancy outcome and that infertility factor LEFTY2 downregulates trypsin induced Ca<sup>2+</sup> increase due in part by interference with nifedipine sensitive Ca<sup>2+</sup> entry. These findings contribute further to our knowledge of unexplained infertility and failed assisted reproductive technologies.
Authors
- Sara Y. Brucker (ORCID: https://orcid.org/0000-0001-5162-1542)
- Melanie Henes (ORCID: https://orcid.org/0000-0002-8844-5922)
- Jing Yan (ORCID: https://orcid.org/0000-0002-0307-1635)
- Madhuri S. Salker (ORCID: https://orcid.org/0000-0002-7939-289X)
- Zhiqi Yang (ORCID: https://orcid.org/0000-0002-4139-4371)
- Florian Läng (ORCID: https://orcid.org/0000-0003-2962-1540)
- Md. Alauddin (ORCID: https://orcid.org/0000-0002-1953-6492)
- Steffen Kull
Institutions
- University Children's Hospital Tübingen (DE)
- Jining Medical University (CN)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fcell.2025.1499339
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Eberhard Karls Universität Tübingen