Causal relationship between hepatic function indicators and thrombocytopenia risk in early-stage hepatitis B virus infection: evidence from clinical observational studies and mendelian randomization analyses
This study identified multiple hepatic function indicators as independent factors associated with thrombocytopenia risk. Notably, our findings provided the first dual confirmation of the causal effect of the injury indicator ALT on thrombocytopenia risk, as evidenced by both clinical observational studies and genetics-based MR analyses, prior to the development of liver cirrhosis.
Authors
- Ya Fu (ORCID: https://orcid.org/0000-0002-7630-4233)
- Can Liu (ORCID: https://orcid.org/0009-0003-8259-5174)
- Shitao Rao (ORCID: https://orcid.org/0000-0002-3604-4684)
- Shuai Zhi
- Hongyan Guo (ORCID: https://orcid.org/0000-0001-6917-5341)
- Tian-bin Chen
- Yanling Hu (ORCID: https://orcid.org/0000-0002-0477-026X)
- Qishui Ou (ORCID: https://orcid.org/0000-0002-9923-3212)
- Xiaotong Chen (ORCID: https://orcid.org/0000-0002-9997-554X)
- Yun‐Yun Zeng
- Jian-wei Jiang
Institutions
- Fujian Medical University (CN)
- Chinese University of Hong Kong (HK)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1440317
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China