Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation
This study reveals immune-metabolic dysregulation as a key driver of MetS-MIRI, proposes five biomarkers for diagnosis, and highlights dexamethasone as a promising therapeutic candidate.
Authors
- Shouyuan Tian (ORCID: https://orcid.org/0009-0006-2680-9918)
- Shufang Liu (ORCID: https://orcid.org/0000-0003-3766-2932)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-3468-6309)
- Ping Wu (ORCID: https://orcid.org/0000-0002-0788-6268)
- Sijin Li (ORCID: https://orcid.org/0000-0002-3230-5170)
- Yanan Zhao (ORCID: https://orcid.org/0000-0002-3679-6392)
- Han‐Qing Pang (ORCID: https://orcid.org/0000-0003-3472-5272)
- Zhifang Wu
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1567572
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39