Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models
These results revealed the key role for CHIT1 in regulating metabolism. OATD-01 is a macrophage modulator that can directly restore metabolic balance and consequently inhibit inflammation and fibrosis, supporting its use for MASH treatment.
Authors
- Angelika Muchowicz (ORCID: https://orcid.org/0000-0003-4707-1722)
- Kamil Lisiecki (ORCID: https://orcid.org/0000-0001-6757-4074)
- Krzysztof Zabłocki (ORCID: https://orcid.org/0000-0002-9987-1257)
- Adam K. Jagielski (ORCID: https://orcid.org/0000-0002-4331-1816)
- Marcin Grzybowski (ORCID: https://orcid.org/0000-0002-5197-7538)
- Katarzyna Drzewicka
- Adam Gołȩbiowski (ORCID: https://orcid.org/0000-0001-5960-2995)
- Tristram A. J. Ryan (ORCID: https://orcid.org/0000-0003-0278-1878)
- Katarzyna Głuchowska
- Michał Mlącki (ORCID: https://orcid.org/0000-0002-4034-6933)
- Luke O'neill (ORCID: https://orcid.org/0000-0002-4333-2748)
- Irina Tuszyńska (ORCID: https://orcid.org/0000-0001-5741-8545)
- Barbara Dymek (ORCID: https://orcid.org/0000-0002-1003-2538)
- Tomasz Rejczak
- Dylan G. Ryan (ORCID: https://orcid.org/0000-0003-4553-9192)
- Bartosz Wilczyński (ORCID: https://orcid.org/0000-0002-9624-6309)
- Katarzyna Piwowar (ORCID: https://orcid.org/0000-0001-6191-0778)
- Zbigniew Zasłona (ORCID: https://orcid.org/0000-0003-3361-4140)
- Bartłomiej Hofman (ORCID: https://orcid.org/0000-0002-1188-8186)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Trinity College Dublin (IE)
- United Technologies Corporation (Poland) (PL)
- University of Warsaw (PL)
- MRC Mitochondrial Biology Unit (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1544973
- Citations
- 1
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.81