Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy
The percentage change in SIR(EOM/temporalis)<sub>MAX</sub> following TCZ treatment and baseline TRAb can serve as predictors of the necessity for surgical intervention in hormone-resistant DON. These indicators assist in the personalization of TCZ therapy and in the avoidance of unnecessary surgical procedures.
Authors
- Kang Xue (ORCID: https://orcid.org/0000-0003-4621-0217)
- Haifeng Chen (ORCID: https://orcid.org/0000-0003-3934-7311)
- Hongyue Tao (ORCID: https://orcid.org/0000-0003-0681-1229)
- Zhiyu Peng
- Jin-Wei Cheng (ORCID: https://orcid.org/0000-0001-9616-4525)
- Hongguang Cui (ORCID: https://orcid.org/0000-0001-7311-0188)
- Jinghan Wang (ORCID: https://orcid.org/0000-0002-8932-0267)
- Qian Jiang (ORCID: https://orcid.org/0000-0002-8504-7857)
- Hongying Ye (ORCID: https://orcid.org/0000-0002-6932-3145)
- Jie Guo (ORCID: https://orcid.org/0000-0001-6104-9957)
- Yiming Li
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-3946-5791)
- Lu Li (ORCID: https://orcid.org/0000-0003-1643-1684)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-5674-7283)
- Ruiqi Ma (ORCID: https://orcid.org/0000-0003-4340-2862)
- Mingxu Yan
- Lu Gan (ORCID: https://orcid.org/0000-0003-4641-9336)
- Binbin Xu
- Wenjun Shu (ORCID: https://orcid.org/0000-0002-0444-6873)
- Fangfang Zeng (ORCID: https://orcid.org/0000-0002-8486-9808)
- Xintong Lin
- Heng Lou
Institutions
- Shanghai Medical College of Fudan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Huashan Hospital (CN)
- Shandong Eye Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1556742
- Citations
- 3
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China