DOCK2 protects against bacterial sepsis by constraining T helper 1 response
Our data indicates that DOCK2 acts as a protective role in regulating systemic inflammation and multi-organ injury in bacterial sepsis by constraining Th1 response. These findings provide new targets for immunomodulatory therapy of sepsis, suggesting that targeting the DOCK2-Th1 axis may become a new strategy to improve systemic inflammatory responses associated with bacterial infections.
Authors
- Ting Liang (ORCID: https://orcid.org/0000-0003-4121-0787)
- Shusen Ye (ORCID: https://orcid.org/0000-0003-4518-0781)
- Lisi Zhu
- Lilin Ye (ORCID: https://orcid.org/0000-0003-0778-3311)
- Chunmin Zhang (ORCID: https://orcid.org/0000-0003-4624-6818)
- Haoyuan Yu (ORCID: https://orcid.org/0000-0001-5873-3715)
- Yifei Wang (ORCID: https://orcid.org/0000-0002-9918-2865)
- Shanshan Liu (ORCID: https://orcid.org/0009-0007-0775-5616)
- Xiangyang Wang (ORCID: https://orcid.org/0000-0003-2276-539X)
- Fan Wu (ORCID: https://orcid.org/0000-0001-5750-7775)
- Linzi Huang
- Yuhao Zheng (ORCID: https://orcid.org/0009-0008-1216-1684)
- Yingjiao Cao (ORCID: https://orcid.org/0000-0003-1689-0397)
Institutions
- Army Medical University (CN)
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1527934
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province