Significance of the peripheral blood Treg/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain/amplification
A potential mechanistic connection exists between 1q21 gain/amplification and immunosuppression, and the role of the <i>MYC</i> gene in this mechanism has garnered substantial interest. Patients with a higher Treg/Th17 ratio at diagnosis are more prone to relapse. The combination of R2-ISS staging and the Treg/Th17 ratio at diagnosis demonstrates stronger predictive ability for relapse.
Authors
- Xiaogong Liang (ORCID: https://orcid.org/0000-0003-3429-7562)
- Jing Yue
- Jingjing Wen (ORCID: https://orcid.org/0000-0002-6994-9025)
- Ya Zhang (ORCID: https://orcid.org/0000-0002-0426-333X)
- Yiping Liu (ORCID: https://orcid.org/0000-0003-1446-6402)
- Fang Xu (ORCID: https://orcid.org/0000-0001-6936-7079)
- Qiaolin Zhou (ORCID: https://orcid.org/0000-0003-0022-0567)
Institutions
- Mianyang Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1595613
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00