Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer
The study suggests that targeting pathways regulating macrophage polarization or enhancing naive B cell activation could play a crucial role in addressing radiotherapy resistance. The findings highlight the potential therapeutic targets, thereby advancing the understanding of the molecular mechanisms underlying radiotherapy resistance in NSCLC, with implications for improving patient management and outcomes.
Authors
- Shun Yue
- Chunyang Yu (ORCID: https://orcid.org/0000-0003-1175-8362)
- Jie Lv (ORCID: https://orcid.org/0000-0002-0239-9188)
- Xiaohang Hu (ORCID: https://orcid.org/0009-0003-0337-4841)
- Yaozu Xiong
- Tingting Dai (ORCID: https://orcid.org/0000-0003-0534-6724)
- Peter H. Pan
- Changhua Yu
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1574113
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52