A-485 alleviates postmenopausal osteoporosis by activating GLUD1 deacetylation through the SENP1-Sirt3 signal pathway
A-485 ameliorates postmenopausal OP by activating GLUD1 deacetylation via the SENP1-Sirt3 signal pathway, thus improving mitochondrial function, and promoting osteogenic differentiation and mineralization.
Authors
- Jiaxin Dong (ORCID: https://orcid.org/0000-0001-6041-123X)
- Qianhong Jian
- Xiaohua Zou (ORCID: https://orcid.org/0000-0002-3489-9152)
- Yue Zhai (ORCID: https://orcid.org/0000-0002-9733-7042)
- Qian Li (ORCID: https://orcid.org/0000-0002-6802-3343)
- Xi Huang (ORCID: https://orcid.org/0009-0008-5667-2662)
- Yinghong Ma
Institutions
- Guiyang Medical University (CN)
- Guizhou Cancer Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s13018-025-05839-4
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61