MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection
These findings establish miR-141 and miR-211 as critical modulators of HSV-2-induced inflammasome activation, highlighting a novel miRNA-based regulatory mechanism. Restoring these miRNAs significantly reduces viral replication and inflammation, underscoring their potential as therapeutic targets for managing HSV-2-induced immunopathology. Future research should focus on <i>in vivo</i> validation and therapeutic optimization to develop miRNA-based interventions.
Authors
- Anwesha Banerjee (ORCID: https://orcid.org/0000-0002-2671-4074)
- Anupam Mukherjee (ORCID: https://orcid.org/0000-0002-0612-2258)
- Ashwini More (ORCID: https://orcid.org/0000-0001-8757-4223)
- Debashree Dass (ORCID: https://orcid.org/0009-0001-8264-0065)
Institutions
- National AIDS Research Institute (IN)
- ICMR-National Institute of Virology (IN)
- Savitribai Phule Pune University (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fcimb.2025.1602965
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis National Research Foundation
- National Research Foundation
- Department of Science and Technology, Ministry of Science and Technology, India
- Department of Health Research, India