TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells
TCF7 contributes to the immunopathology of PH possibly through upregulation of stressed NK cells. Under stress conditions, NK cells promote the proliferation and migration of hPASMC through paracrine effects, thereby further promoting vascular remodeling.
Authors
- Xiaohe Xu (ORCID: https://orcid.org/0009-0008-8493-0235)
- Chenyu Jiang (ORCID: https://orcid.org/0000-0003-2964-2309)
- Xing-Liang Zhou
- Xu Huang (ORCID: https://orcid.org/0009-0008-9966-3280)
- Chunlei Shi (ORCID: https://orcid.org/0000-0002-5847-7122)
- Lincai Ye (ORCID: https://orcid.org/0000-0001-8808-2810)
- Yangyang He (ORCID: https://orcid.org/0000-0002-3517-572X)
- Yiwei Liu
- Tianyu Liu (ORCID: https://orcid.org/0000-0003-3735-3814)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-6129-0342)
- Min Chen (ORCID: https://orcid.org/0000-0003-0419-743X)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-9373-5211)
- Dai‐Ji Jiang
- Liwei Wu (ORCID: https://orcid.org/0000-0002-3150-2260)
- Yi Yan (ORCID: https://orcid.org/0000-0002-0982-0713)
- Yi Shen (ORCID: https://orcid.org/0000-0003-1756-9423)
- Bei Feng (ORCID: https://orcid.org/0000-0002-8476-8628)
Institutions
- North Sichuan Medical University (CN)
- Henan University (CN)
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Shanghai Children's Medical Center (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s12931-025-03276-9
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04