Analysis of Lipid Profile and Vitamin E Status in Pregnancy-Induced Hypertension

Background: Pregnancy-Induced Hypertension (PIH) affects 5-10% of pregnancies worldwide and is associated with oxidative stress, endothelial dysfunction, and dyslipidemia. It is particularly prevalent in low-income regions. This study examines the correlation between lipid profiles, Vitamin E levels, and PIH in pregnant women to identify potential therapeutic interventions. Methods: A cross-sectional study was conducted at Sheikh Khalifa Bin Zayed Al Nahyan Hospital, Pakistan, from March 2022 to March 2023. A total of 150 pregnant women were included, with 75 diagnosed with PIH and 75 normotensive controls, selected using non-probability consecutive sampling. Lipid profile parameters (total cholesterol, triglycerides, HDL, LDL) and Vitamin E levels were measured using standard biochemical assays. Statistical analyses were conducted using SPSS 24.0, applying chi-square tests, descriptive statistics, and Pearson’s correlation coefficient, with significance set at p<0.05. Results: The PIH group exhibited significantly higher systolic and diastolic blood pressure (p=0.001). No significant differences in lipid profile parameters were found between the two groups. However, Vitamin E deficiency was more prevalent in the PIH group, 59 (78.67%), compared to the normotensive group, 25 (33.33%). No significant correlation was observed between lipid profiles and Vitamin E levels. Conclusion: Vitamin E deficiency may contribute to PIH pathogenesis, despite no observed lipid profile differences between groups. Further research on antioxidant supplementation and lipid regulation in PIH is recommended.