The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4
Germacrone can protect the liver by inhibiting the Nrf2/Rbp4 signaling pathway, improving oxidative stress and lipid metabolism disorder in the ALD model. Rbp4 is a novel downstream target gene of Nrf2. As a potential drug candidate, Germacrone has great clinical application value.
Authors
- Xia Ou
- Shuhua Gui
- Yiyuan Zhong (ORCID: https://orcid.org/0000-0001-5164-7734)
- M.-J. Wang (ORCID: https://orcid.org/0000-0002-0423-7561)
- Yunhong Zhang (ORCID: https://orcid.org/0000-0002-2899-5068)
- Zeren Dawa (ORCID: https://orcid.org/0000-0001-5865-2085)
- Yongling Long (ORCID: https://orcid.org/0000-0003-2533-7614)
- Jiamin Fang
- Tianqin Xiong (ORCID: https://orcid.org/0000-0002-5996-0589)
- Xiao Ru
- Changhui Liu (ORCID: https://orcid.org/0000-0001-6165-4313)
- Guolin He (ORCID: https://orcid.org/0000-0003-4950-0586)
- Yang De
- Qinpo Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s13020-025-01132-y
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University