Responsiveness of different MET tumour alterations to type I and type II MET inhibitors
Kinase mutations in RTKs are primary or secondary drivers in multiple cancer types Some of these mutations confer resistance to type I but not to type II inhibitors in preclinical samples and in patients The biochemical characterization of mutations in oncogenic kinases based on their sensitivity to type I and type II inhibitors is crucial to inform clinical intervention.
Authors
- Lia Judka
- Madeline Merrill
- Erica Sgroe
- Helena A. Yu (ORCID: https://orcid.org/0000-0002-0377-9510)
- Srinivasaraghavan Kannan
- Estelamari Rodríguez (ORCID: https://orcid.org/0000-0001-8132-4573)
- Jason Chang
- Yonina R. Murciano‐Goroff (ORCID: https://orcid.org/0000-0001-9027-2891)
- Shaza Ahmed (ORCID: https://orcid.org/0000-0001-5258-0586)
- Michael F. Berger (ORCID: https://orcid.org/0000-0003-3882-5000)
- Emiliano Cocco (ORCID: https://orcid.org/0000-0002-1397-2656)
- Chandra Shekhar Verma (ORCID: https://orcid.org/0000-0003-0733-9798)
- Paola Roa (ORCID: https://orcid.org/0009-0009-0788-8499)
- Jamie Gibson
- Alexander Edward Dela Cruz Drilon (ORCID: https://orcid.org/0000-0001-6806-9061)
- Valentina Foglizzo (ORCID: https://orcid.org/0000-0001-5059-3279)
- Matteo Repetto (ORCID: https://orcid.org/0009-0002-4943-630X)
- Karen R. Clemens
- Zsofia Kinga Stadler (ORCID: https://orcid.org/0000-0002-6985-2864)
- Eneda Toska (ORCID: https://orcid.org/0000-0002-8974-9792)
- Natasha Rekhtman (ORCID: https://orcid.org/0000-0001-5801-3144)
- Nicole V. Bremer
- Ann Elizabeth Sisk
- Courtney Lynn Binaco
- Sherifah Kemigisha Muzungu
Institutions
- Agency for Science, Technology and Research (SG)
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- University of Miami (US)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Kettering University (US)
- Computational Diagnostics (United States) (US)
- Bioinformatics Institute (SG)
- Molecular Oncology (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ctm2.70338
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Lung Cancer Research Foundation
- National Institutes of Health