Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial Sepsis
Mortality in endotoxemia and sepsis is exacerbated by impaired hepatic Nrf1 activity. Interventions increasing hepatic Nrf1 activity promote liver defenses that protect against sepsis-associated hypothermia and mortality.
Authors
- May G. Akl (ORCID: https://orcid.org/0000-0001-8062-3985)
- Scott B. Widenmaier (ORCID: https://orcid.org/0000-0001-5684-2707)
- Michael J. Trites (ORCID: https://orcid.org/0000-0002-3696-2792)
- Uche Njoku (ORCID: https://orcid.org/0000-0002-4684-1812)
- Aidan Hydomako
- Lei Li (ORCID: https://orcid.org/0000-0002-2702-7444)
Institutions
- University of Saskatchewan (CA)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101550
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Heart and Stroke Foundation of Canada
- University of Saskatchewan
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada